Symptomatic Atherosclerotic Plaques as a Basis of Prostaglandin E Overexpression of Functionally Coupled Cyclooxygenase-2 and Prostaglandin E Synthase in
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چکیده
Cuccurullo Annalisa Iezzi, Sante Ucchino, Gianfranco Boccoli, Vittorio Saba, Francesco Chiarelli, Franco Francesco Cipollone, Cesaria Prontera, Barbara Pini, Matteo Marini, Maria Fazia, Domenico De Cesare, -Dependent Plaque Instability 2 Symptomatic Atherosclerotic Plaques as a Basis of Prostaglandin E Overexpression of Functionally Coupled Cyclooxygenase-2 and Prostaglandin E Synthase in Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2001 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/hc3401.093152 2001;104:921-927 Circulation. http://circ.ahajournals.org/content/104/8/921 Wide Web at: The online version of this article, along with updated information and services, is located on the World
منابع مشابه
Overexpression of functionally coupled cyclooxygenase-2 and prostaglandin E synthase in symptomatic atherosclerotic plaques as a basis of prostaglandin E(2)-dependent plaque instability.
BACKGROUND Studies have implicated a role for prostaglandin (PG) E(2)-dependent matrix metalloproteinase (MMP) biosynthesis in the rupture of atherosclerotic plaque. Cyclooxygenase-2 (COX-2) and PGE synthase (PGES) are coregulated in nucleated cells by inflammatory stimuli. The aim of this study was to characterize the expression of COX-2 and PGES in carotid plaques and to correlate it with the...
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OBJECTIVE We recently demonstrated that inducible cyclooxygenase/PGE synthase-1 (COX-2/mPGES-1) are overexpressed in symptomatic plaques in association with PGE2-dependent metalloproteinase (matrix metalloproteinase [MMP]) biosynthesis and plaque rupture. However, it is not known which of the 4 PGE2 receptors (EP1-4) mediates macrophage metalloproteinase generation. The aim of this study was to...
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Objective—Inducible cyclooxygenase (COX-2) catalyzes the first step in prostanoid biosynthesis and is considered a proinflammatory enzyme. COX-2 and type 1 inducible PGE synthase (mPGES-1) have a role in metalloproteinase (MMP) release leading to plaque rupture. In contrast, lipocalin-type PGD synthase (L-PGDS) has been shown to exert antiinflammatory actions. Thus, in this study we investigate...
متن کاملNOD2-mediated innate immune signaling regulates the eicosanoids in atherosclerosis.
OBJECTIVE The activity of eicosanoid pathways is critical to the inflammatory and immune responses that are associated with the progression of atherosclerosis. Yet, the signals that regulate these pathways are poorly understood. Here, we address whether the innate immune signals of nucleotide-binding oligomerization domain-containing protein (NOD) 2 affect eicosanoids metabolism in atherosclero...
متن کاملThe balance between PGD synthase and PGE synthase is a major determinant of atherosclerotic plaque instability in humans.
OBJECTIVE Inducible cyclooxygenase (COX-2) catalyzes the first step in prostanoid biosynthesis and is considered a proinflammatory enzyme. COX-2 and type 1 inducible PGE synthase (mPGES-1) have a role in metalloproteinase (MMP) release leading to plaque rupture. In contrast, lipocalin-type PGD synthase (L-PGDS) has been shown to exert antiinflammatory actions. Thus, in this study we investigate...
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